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KMID : 0984920080100010044
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Journal of Skin Barrier Research
2008 Volume.10 No. 1 p.44 ~ p.54
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The effect of skin surface on epidermal permeability barrier
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Kim Hyun-Jung
Lee Seung-Hun
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Abstract
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Our recent understandings of the skin barrier function (the defensive function of stratum corneum) can be summarized as not only multiple but also “linked and co-regulatory” activities. To maintain the normal skin barrier function from xeric environment, infective agents, toxic chemicals and UV light, the epidermis has unique regulatory mechanism. Even the single stressor can modulate multiple defensive functions of stratum corneum. Skin surface is in acidic pH condition which is different from neutral pH of core part. So called “acid mantle”of stratum corneum is essential for the epidermal barrier homeostasis. sPLA2(soluble phospholipase 2), sodiun hydrogen exchanger and ceramidase are considers as the makers of “acid mantle”. The change of skin surface pH as the stressor for SC defensive function affects on multiple barrier functions such as intact epidermal permeability barrier, SC integrity/ cohesion and antimicrobial barrier function. The exact receptors and mechanisms for sensing the pH change and modulation the barrier function can be the new area for skin pH and barrier study.
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KEYWORD
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skin surface pH, epidermal permeability barrier, SC integrity/cohesion, serine protease
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